For Author's Instructions and Aims & Scope: Visit:
Citation: Gowri R., Narayanan N., 2014. Impact of H2 receptorantagonist in acid inhibition. International Journal of Pharmacy. InternationalJournal of Pharmacy. Photon 105, 404-410
Abstract
Histamine is anaturally occurring chemical that stimulates cells in the stomach to produceacid. It was synthesized in 1907 and found to be a natural constituent inmammalian tissues. H1, H2, H3 are the three types of histamine receptors. The H2receptor antagonists are a class of drugs used to block the action of histamineon parietal cells in the stomach decreasing the production of acid by thesecells. H2- blocker maintenance therapy is cost-effective and is associated withsignificantly less morbidity. H1 receptors mediate on smooth muscle leading to vasodilation,H2 receptors mediate histamine stimulation of gastric acid secretion and H1 receptorsfeedback inhibitors in CNS, gastric acid secretion, lungs. The H2 antagonistsoffer several advantages over antacids, including longer duration of action(6-10 hours vs 1-2 hrs for antacids), greater efficacy, and ability to useprophylactically before meals to reduce the chance of heartburn occurring. Theyare used for the treatment of symptoms of gastroesophageal reflux disease (GERD)and for the treatment of esophagitis they have also been used in combinationwith antibiotics for the treatment of peptic ulcers. In over-thecounter (OTC)strengths, these medicines are used to relieve and/or prevent heartburn, acidindigestion and sour stomach. This review focuses the current data on clinicalpharmacology, therapeutic indications and results of the H2 receptor antagonistdrugs like Cimetidine, Ranitidine, Famotidine, Nizatidine. This review throwsan insight to inception of the H2 receptor antagonists and its progressivegrowth towards the repression of acid secretion.
Abstract
|
